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Precision Gene Editing
CRISPR-based nucleases, base editors and prime editors that rewrite single DNA letters without cutting both strands.
- Fewer off-target edits
- Guide RNA design with machine learning
- Ex vivo and in vivo use
Bioscience startup · Founded 2024
Engineering biology for earlier, more precise medicine
NovaGen Biosciences combines gene editing, targeted delivery, early-detection diagnostics and synthetic biology to turn discoveries in the lab into treatments and tests that reach patients.
4Active research programs
3Core technology platforms
28Scientists & engineers
10+Academic & clinical partners
Biology 101
How life's code becomes health, and where we step in
Every cell reads instructions stored in DNA. Disease often begins when those instructions are changed, misread or switched on at the wrong time. Understanding this flow shows exactly where modern biotechnology can intervene.
STEP 1
DNA
Roughly 3 billion letters (A, T, G, C) store the genetic blueprint. Gene editing acts here, correcting or disabling faulty sequences.
STEP 2
RNA
Genes are copied into messenger RNA (mRNA). RNA-based medicines act here to turn gene activity up or down.
STEP 3
Protein
Ribosomes translate mRNA into proteins, the machines of the cell. Engineered enzymes and antibodies act here.
STEP 4
Function
Proteins build tissue, signal, defend and metabolize. Diagnostics detect biomarkers when this goes wrong.
Technology platforms
Four capabilities, one integrated discovery engine
Each platform strengthens the others: better design improves editing, better delivery widens what can be treated, and better diagnostics find the right patients sooner.
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Targeted Delivery
Lipid nanoparticles and engineered viral vectors that carry editors to the right tissue and nowhere else.
- Liver, blood and immune cell targeting
- Redosable, non-integrating options
- Scalable GMP-ready formulation
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Early-Detection Diagnostics
Blood-based tests that read cell-free DNA (cfDNA) fragments and methylation patterns to flag disease before symptoms.
- Multi-cancer signal detection
- Non-invasive liquid biopsy
- Sequencing plus AI classification
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Synthetic Biology
Engineered enzymes and microbes that manufacture therapeutics, biomaterials and sustainable chemicals.
- Directed evolution of enzymes
- Cell-free protein production
- Lower-carbon manufacturing
How we work
From target to translation
A disciplined, data-driven loop that cuts wasted effort and moves only the strongest candidates forward.
Target identification
Genomics and patient data reveal genes and pathways that causally drive disease.
Design & modeling
Computational models predict editor, guide and delivery performance before any bench work.
Validation
Cell models, organoids and animal studies test efficacy, specificity and safety.
Translation
Regulatory-grade manufacturing, IND-enabling studies and clinical partnerships.
Hover or tap a step to explore it. Move your mouse over the background to interact with the molecular network.
Pipeline
Programs advancing toward the clinic
Development typically spans 10 to 15 years through discovery, preclinical work and phase 1, 2 and 3 trials. Here is where each NovaGen program stands today.
| Program | Area | Modality | Stage | Progress |
|---|---|---|---|---|
| NG-101 | Oncology | Base-edited T-cell therapy | Preclinical | |
| NG-204 | Rare metabolic disease | In vivo gene correction (LNP) | Lead optimization | |
| NG-310 | Diagnostics | cfDNA multi-cancer early detection | Clinical validation | |
| NG-405 | Synthetic biology | Engineered enzymes for green manufacturing | Discovery |
Learn
Bioscience glossary, in plain language
New to the field? These short explainers cover the terms you will meet most often.
CRISPR-Cas9
A system adapted from bacterial immune defense. A guide RNA leads the Cas9 protein to a matching DNA sequence, where it makes a cut that the cell then repairs, allowing genes to be disabled or corrected.
Base and prime editing
Next-generation editors that change individual DNA letters, or insert short sequences, without making a full double-strand break. This improves precision and reduces unwanted changes.
mRNA and lipid nanoparticles (LNPs)
mRNA carries temporary instructions for making a protein. LNPs are tiny fat-based bubbles that protect mRNA and deliver it into cells, the same approach used in mRNA vaccines.
Biomarker
A measurable signal such as a protein, hormone or DNA fragment in blood that reveals normal biology, disease or response to treatment.
Liquid biopsy and cfDNA
Cells release small DNA fragments into the bloodstream. Reading their sequence and chemical tags can reveal cancer-related changes from a simple blood draw.
Genomics and sequencing
Genomics studies the complete set of genes. Next-generation sequencing reads millions of DNA fragments in parallel, making whole-genome analysis fast and affordable.
Synthetic biology
An engineering approach to biology: standardized genetic parts are designed, built and tested to give cells new abilities, such as producing a medicine.
Clinical trial phases
Phase 1 tests safety in small groups, phase 2 explores effectiveness and dosing, and phase 3 confirms benefit in large populations before regulators review approval.
Research
Selected publications & milestones
Peer-reviewed science and open data underpin everything we build. (Sample entries for demonstration.)
2026
Improved specificity of adenine base editors using structure-guided guide design
Preprint · Genome Engineering
2026
Tissue-selective lipid nanoparticles enable redosable in vivo editing
Journal of Nanomedicine
2025
Methylation-based cfDNA classifier detects early-stage cancers across multiple tissues
Clinical Genomics Letters
2025
Directed evolution of a thermostable enzyme for low-energy biomanufacturing
Synthetic Biology Reports
Responsibility
Safety, ethics and data stewardship
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Safety first
Every candidate faces off-target analysis, toxicity screening and independent review before progressing.
⚖️
Ethical research
Our work focuses on treating disease in somatic cells. Heritable (germline) editing is outside our scope.
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Patient privacy
Genomic data is de-identified, encrypted and used only with informed consent and regulatory oversight.
Leadership
Scientists, clinicians and builders
A multidisciplinary team spanning molecular biology, bioinformatics, clinical development and manufacturing. (Placeholder profiles.)
AR
Dr. A. Rao
Chief Executive OfficerMolecular biologist and serial founder.
LM
Dr. L. Moreau
Chief Scientific OfficerGene-editing researcher, 40+ papers.
KS
Dr. K. Sato
Head of Computational BiologyMachine learning for genomics.
JO
Dr. J. Okafor
Chief Medical OfficerClinical trial design and regulatory strategy.
Join us in engineering biology
Open roles in research, bioinformatics, process development and clinical operations.
Events
Upcoming webinars, lab days and workshops
Meet our scientists, see the lab and learn the science. Most events are free; register by email and we will send joining details. (Sample dates for demonstration.)
12NOV
Base editing explained: from lab to clinic
Online · 4:00 PM IST · Webinar with our Chief Scientific Officer
03DEC
Open Lab Day for students & the public
Innovation Park · 10:00 AM · Lab tours, live demos, Q&A with researchers
21JAN
Hands-on workshop: intro to genomics & bioinformatics
Hybrid · Full day · Python and sequence-analysis basics
17FEB
Investor & partner briefing: pipeline update
Online · By invitation · Program progress and partnership opportunities
10MAR
Liquid biopsy and early cancer detection
Online · 4:00 PM IST · Webinar on cfDNA diagnostics
Submit ideas
Got an idea? We want to hear it
Good science comes from many minds. Share a research concept, a product or technology idea, a partnership proposal, an education or outreach suggestion, or feedback on this website.
- Every submission is read by our science team
- Promising ideas receive a reply within 10 working days
- Please do not share confidential or patient-identifiable data
Work with us
Six ways to build the future of biology with us
Whether you want a career, a collaboration or a partnership, there is a place for you.
Join usRead the code of life with us. Move your mouse across the trace to read the bases.
See open roles💼
Careers
Full-time roles in research, data science, process development and clinical operations.
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Internships & fellowships
3 to 6 month placements for students and early-career scientists with real project ownership.
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Research collaboration
Joint studies with universities, hospitals and institutes, including shared data and sample access.
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Industry partnerships
Licensing, co-development and manufacturing partnerships with pharma and biotech companies.
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Investors
Early access to our pipeline updates, data room and quarterly briefings.
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Scientific advisors
Join our advisory network of clinicians and researchers who guide strategy and trial design.
Open roles
Computational Biologist
Research · Full-time · HybridGene Editing Scientist
Research · Full-time · On-siteProcess Development Engineer
Manufacturing · Full-time · On-siteClinical Operations Manager
Clinical · Full-time · HybridBioinformatics Intern
Internship · 6 months · RemoteFollow us
News, papers, events and behind-the-scenes lab stories, plus our monthly science newsletter.
Tip: click anywhere on this panel to pop the cells.
FAQ
Frequently asked questions
What is gene editing?
Gene editing uses molecular tools such as CRISPR to make precise changes to DNA, correcting or switching off genes that drive disease.
What is a biomarker?
A biomarker is a measurable biological signal, such as a protein or fragment of DNA in blood, that indicates a normal or disease state.
What is synthetic biology?
Synthetic biology designs and builds new biological parts, enzymes and organisms for medicine, materials and sustainable manufacturing.
How long does drug development take?
From discovery to approval typically takes 10 to 15 years, passing through preclinical studies and phase 1, 2 and 3 clinical trials.
Can I collaborate or invest?
Yes. We welcome research collaborations, licensing discussions and investor conversations. Use the contact form below or talk to our virtual assistant, Simo.
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Contact
Let's talk science
Collaboration, investment, press or careers: tell us how we can help and the right person will reply.
Email: hello@novagen-bio.example
Labs: Innovation Park, Biotech Corridor